Bioinorganic Chemistry

 

Course Contents:

Introduction: Transition metal ions in biology. Metalobiomolecules. Electron carriers, oxygen carriers, enzymes. Biogeoinorganic chemistry, environment.

example of metalloenzymes: Hemoglobin, Myoglobin, Hemocyanin, Hemrythrin cytochromes, Fe-S proteins, Cytochrome P-450, Nitrophorin, NO-synthase, peroxidase, catalase, Ferritin, cytochrome-C oxidase, cerulplasmin, blue copper proteins, di and tricopper proteins. Other enzymes like, hydrogenase, methane monooxygenase, dioxygenases, dehydratase, nitrogenase, molybdenum containing oxidase and reductase class of enzymes like sulfite oxidase, xanthine oxidase, nitrate reductase, nitrite reductase, Nitric oxide reductase, Nitrous oxide reductase, DMSO reductase, tungsten containing formate dehydrogenase and tungsten bearing hyperthermophilic and thermophilic enzymes. Zn enzymes like carbonic anhydrase, carboxypeptidase, DNA and RNA polymerases, role of manganese in water splitting.

Active site analogue functional models and structural models of these enzymes.

Environmental chemistry, arsenic and other heavy metal pollutions.

Inorganic chemistry in medicine, platinum complexes, Mo=S complexes as anti-cancer drugs.

Photodynamic therapy of cancer Cells.

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Reference Books:

1.  Principles of bioinorganic chemistry: By S J Lippard and J M Berg. pp 411. University Science Books, Mill Valley, California. 1994.

2.  Biological Inorganic Chemistry. Structure and Reactivity. Edited by Ivano Bertini, Harry B. Gray, Edward I. Stiefel and Joan S. Valentine,pp 739. University Science Books, Sausalito 2007.

3. Bioinorganic Chemistry, A Survey, By Ei-Ichiro Ochiai, 1st Edition, pp 360. Academic Press, Elsevier 2009.

4. Bioinorganic Chemistry: A Short Course 1st Edition, By Rosette M. Roat-Malone, pp 376. Wiley-Interscience, 2008.

5. Bioinorganic Chemistry, By A. K. Das, Books & Allied (P) Ltd. Kolkata 2007.

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Inorganic Photochemistry

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Course Contents:

Introduction to inorganic photochemistry, photophysical and photochemical process. Excitation modes in transition metal complexes, fate of photo-excited species, fluorescence and phosphorescence applied to Inorganic systems, intramolecular energy transfer, vibrational relaxation, internal conversion and intrasystem crossing, quantum yield, decay fluorescence. Fluorescence quenching, Stern-Volmer equation. Photochemical process: photo substitution and photoelectron transfer reactions in Co, Cr, Ru and Rh complexes. Photosensitization, quenching, charge and energy transfer, prompt and delayed reactions, excimer structure, substitution, fragmentation, isomerisation, exchange and redox reactions; chemiluminescence, photochromism; photochemistry using laser beams; chemical actinometry and determination of quantum yield, inorganic photochemistry in biological processes and their model studies; applications of photochemical reactions of coordination compounds - synthesis and catalysis, solar energy conversion and storage.

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Reference Books:

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 W. Adamson and P. D. Fleischauer (Eds.), Concept of Inorganic Photochemistry, Wiley, New York, 1975.

G. L. Geoffroy and M. S. Wrighton, Organometallic Photochemistry, Academic Press, New York, 1970.

R. Hollebone, C. H. Langford and N. Serpone, Inorganic Photochemistry, Coord. Chem. Rev., 1981, 39, 181.

G. stochel, M. brindell, W. macyk, Z. stasicka, K. szacilowski, Bioinorganic Photochemistry, Wiley, 2009

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Organometallic Chemistry

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Course Contents:

Fluxional organometallic compounds: Fluxionality and dynamic equilibria in compounds such as h2 olefins, h3 allyl and dienyl complexes, techniques of study. Metal-alkyl, -allyl, -aryl, -carbene (Fischer and Schrock type), -carbines and cyclopentadienyl complexes Synthesis, bonding, stability, reactivity. Polyalkyls and polyhidrides complexes. Organoboron and Organoaluminium compounds.

 

Reference Books:

R. H. Crabtree, The Organomettalic Chemistry of the Transition Metals, 4th Edn, Wiley, New York, 2005.

P. Powell, Principles of Organometallic Chemistry, 2nd Edn, Chapman and Hall, London, 1988.

G. O. Spessard and G. L. Miessler, Organometallic Chemistry, International 2nd Edn, Oxford University Press, Oxford, 2010.

A. Yamamoto, Organotransition Metal Chemistry, Wiley, New York, 1986.

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Magnetochemistry

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Course Contents:

Basic principles of magnetism, Magnetic properties, paramagnetism, ferro- and antiferro magnetism, diamagnetism, Pascal constants, Currie equation, Russell-sander’s terms, Magnetic properties and coordination compounds. Magnetic properties of first transition series metal ions, lanthanides and actinides, Lanthanide and actinide contractions and their consequences. Basic concept of Single Molecule Magnets (SMM), properties and examples of SMMs.

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Reference Books:

J. S. Miller and M. Drillon (Eds), Magnetism: Molecules to Materials, V; Molecule-based Magnets, Wiley-VCH, Weinheim, 2005.

F. E. Mabbs and D. J. Machin, Magnetism and Transition Metal Complexes, Dover Publications, New York, 2008.

R. Winpenny (Ed), Single-Molecule Magnets and Related Phenomena, Structure and Bonding Series, Vol 122, Springer, Berlin, 2010.

D. Gatteschi, R Sessoli and J. Villain, Molecular Nanomagnets, Oxford University Press, Oxford, 2006.

R. Hilzinger and W. Rodewald, Magnetic Materials, Wiley, New York, 2013.

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Supramolecular Chemistry

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Course Contents:

(a) Host-guest Chemistry: Synthesis and structures of crown ethers, Lariat ethers, Podands, Cryptands, Spherands, Calixarene, Cyclodextrins, Cyclophanes, Cryptophanes, Carcerands and hemicarcerands, Host-guest interactions, Preorganisation and complimentarity, Lock and key analogy, Binding of cationic, Anionic, Ion pair and neutral guest molecules.

(b) Supramolecular Veracities:Self-assembly molecules: Design, Synthesis and Properties of the molecules, Self-assembly by H-bonding, Catenanes, Rotaxanes, Dendrimers and Supramolecular gels. Relevance of supramolecular chemistry to mimic biological system. Supramolecular arrays: ribbon. Ladder, rack, braded, grid. Dendrimers.

(c) Molecular Devices:Molecular Electronic devices, Molecular wires, Molecular rectifiers, Molecular switches and Molecular logic gates. Examples of recent developments in supramolecular chemistry from current literature, molecular recognition.

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Reference Books:

G. A. Jeffrey, An Introduction to Hydrogen Bonding, Oxford University Press, Oxford, 1997.

J. W. Steed and J. L. Atwood, Supramolecular Chemistry, 2nd Edn, John Wiley & Sons, New York, 2009.

R. Martinez-Manez and K. Rurack (Eds), The Supramolecular Chemistry of Organic-Inorganic Hybrid Materials, John Wiley & Sons, Hoboken, New Jersey, 2010.

J . M. Lehn, Supramolecular Chemistry - Concepts and Perspectives, Wiley-VCH, 1995.

P. D. Beer, P. A. Gale and D. K. Smith, Supramolecular Chemistry, Oxford University Press, 1999.